2023 Fiscal Year Final Research Report
Identification of new parathyroid cells, parathyroid maintenance cells (PMCs) , and re-evaluation of parathyroid constituent cells
| Project/Area Number |
20K07252
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 48010:Anatomy-related
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2024-03-31
|
| Keywords | 副甲状腺 / parathyroid / シングルセルトランスクリプトーム / Gcm2 / 主細胞 / 副細胞 / 細胞増殖 |
|---|
| Outline of Final Research Achievements |
In this study, we conducted experiments to reassess parathyroid cells in order to identify the parathyroid maintaining cells (PMCs) responsible for maintaining the function and morphology of parathyroid cells. To classify parathyroid cells in detail, we performed single-cell transcriptome analysis of the parathyroid gland and identified a cell population distinct from chief cells and oxyphil cells. This suggested that these cells could be PMC, and upon examining this cell population in the parathyroid gland, it was found to be located adjacent to blood vessels. From these findings, we confirmed the existence of cells corresponding to PMC and identified the regions where they are located. This result led to an important discovery that opens new doors for research on parathyroid cells.
|
| Free Research Field |
発生学、機能形態学、分子生物学
|
| Academic Significance and Societal Importance of the Research Achievements |
年々増加する慢性腎不全によって、副甲状腺の過形成患者が増加している。副甲状腺の過形成は、過剰なPTHを産生・分泌し、循環器系の重篤な障害につながることが知られており、副甲状腺の過形成を抑制・治療できる方法が求められている。我々は本研究で、副甲状腺に存在する新たな細胞集団（PMC）を同定し、それらが細胞増殖や内分泌機能に大きな役割を果たす可能性を見出した。
PMCの詳細な理解は、副甲状腺の過形成の治療だけでなく、過形成に至る前の予防にも応用可能である。また、これまでの概念を覆す新規細胞の同定という学術的な新規性も持つ研究となった。。
|
