Insufficient function of SWI/SNF in metabolic disorer-related cancer

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K07406
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Gifu University
• Principal Investigator: Takeuchi Tamotsu 岐阜大学, 大学院医学系研究科, 教授 (50226990)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: ARID1A / T-cadherin / adiponectin

Outline of Final Research Achievements

ARID1A is a DNA binding element of chromatin remodeling complex, human equivalent to SWI/SNF complex. It has been well documented that insufficient expression of ARID1A or its function lead various carcinogenesis including that of colon cancer and breast cancer. It is interesting that these ARID1A related malignancy may be overlapped to so called metabolic-disease related cancers.
In the present study, we examined and unraveled that insufficient function of ARID1A was related to adiponectin, especially that of high molecular weight form, and T-cadherin, which is a receptor for high molecular weight adiponectin.

Free Research Field

人体病理

Academic Significance and Societal Importance of the Research Achievements

ARID1A発現低下がもたらす、がん進行に対して、adiponectin補充、とくに、そのhigh molecular weight分子の補充が、必要であることをみいだした。
本研究は、いわゆるメタボリック障害が関連する癌で、adiponectinの重要性をARID1A変異発がんの観点から明らかにした。