innovative therapeutic approach of some devasting respiratory and cardiac diseases via MFALCs targetting

2022 Fiscal Year Annual Research Report

• Project/Area Number: 20K07420
• Research Institution: Hokkaido University
• Principal Investigator: エレワ ヤセル 北海道大学, 獣医学研究院, 助教 (30782221)
• Co-Investigator(Kenkyū-buntansha): 昆 泰寛 北海道大学, 獣医学研究院, 教授 (10178402) ; 市居 修 北海道大学, 獣医学研究院, 准教授 (60547769)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: MFALCs / Bleomycin / Lung Injury / Autoimmune Disease / lymphoproliferative / mouse models

Outline of Annual Research Achievements

This year, we were able to clarify the effects of either dexamethasone or bleomycin on lung injury and mediastinal fat-related lymph nodes (MFALCs). We were able to publish these data in two international high-impact journals (Elewa et al. J. Mol. Sci.2, Elewa et al. 2022, Microscopy and Microanalysis). In addition, we have started a new experiment on the impact of lung cancer induction on the microenvironment in MFALC. By targeting such MFALCs, he suggested that we could provide innovative treatments for lung cancer.In addition, in the previous year, we conducted joint research with other researchers in the laboratory and other research institutions and we have published 2022 more papers from this collaboration.

Research Products

• [Journal Article] Histopathological Impact of Bleomycin on Lung Injury and Development of Mediastinal Fat-Associated Lymphoid Clusters in the Lymphoproliferative Mouse Model (2022)
  • Author(s): Elewa, Y. H. A., Ichii, O., Mohamed, S.K.A., Kon, Y.
  • Journal Title: Microscopy and Microanalysis Volume: 28 Pages: 1664-1678
  • DOI: 10.1017/S1431927622000654
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Ameliorative Effect of Dexamethasone on the Development of Autoimmune Lung Injury and Mediastinal Fat‐Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model (2022)
  • Author(s): Elewa, Y. H. A., Masum Md. A., Mohamed, S.K.A., Islam RM, Nakamura T., Ichii, O., Kon, Y
  • Journal Title: Int. J. Mol. Sci. Volume: 23 Pages: 4449
  • DOI: 10.3390/ijms23084449
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ureteral morphology and pathology during urolithiasis in cats (2022)
  • Author(s): Ichii O, Oyamada K, Mizukawa H, Yokoyama N, Namba T, Otani Y, Elewa, Y. H. A., Sasaki N, Nakamura T, Kon Y.
  • Journal Title: Research in Veterinary Science Volume: 151 Pages: 10-20
  • DOI: 10.1016/j.rvsc.2022.06.029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cellular infiltration, cytokines, and histopathology of skin lesions associated with different clinical forms and stages of naturally occurring lumpy skin disease in cattle (2022)
  • Author(s): Badr Y., Noreldin A.E., Elewa Y.H.A., Ahmed M.S., Inoshima Y., Baker N.M., Aamer W.N., Abas O.M., Nayel M., Rahman Md. M., Elgendy E., Saleh A. G., El-neweshy M.S
  • Journal Title: Comparative Immunology, Microbiology, and Infectious Diseases Volume: 90-91 Pages: 101894
  • DOI: 10.1016/j.cimid.2022.101894
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oral supplementation of policosanol alleviates carbon tetra chloride- induced liver fibrosis in rats. (2022)
  • Author(s): Zein N, Yassin F, Makled S, Alotaibi SS, Albogami SM, Hedeab GM, Batiha GE, Elewa Y.H.A
  • Journal Title: Biomed Pharmacother Volume: 150 Pages: 113020
  • DOI: 10.1016/j.biopha.2022.113020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Modified foreign body reaction to silicone imbedded in subcutaneous tissues by different mouse systemic immune conditions (2022)
  • Author(s): Yamakawa T, Ichii O, Nakamura T, Namba T, Elewa, Y. H. A., Masum MA, Otani Y, Nishimura T, Kon Y.
  • Journal Title: J Biomed Mater Res A. Volume: 110 Pages: 1921-1931
  • DOI: 10.1002/jbm.a.37425
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules (2022)
  • Author(s): Chuluunbaatar T, Ichii O, Masum MA, Namba T, Islam MR, Otani Y, Elewa, Y. H. A., Kon Y.
  • Journal Title: Research in Veterinary Science Volume: 145 Pages: 147-158
  • DOI: 10.1016/j.rvsc.2022.02.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Close Association between Altered Urine-Urothelium Barrier and Tertiary Lymphoid Structure Formation in the Renal Pelvis during Nephritis (2022)
  • Author(s): Ichii O, Hosotani M, Masum MA, Horino T, Otani Y, Namba T, Nakamura T, Elewa, Y. H. A., Sasaki N, Kon Y.
  • Journal Title: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 33 Pages: 88-107
  • DOI: 10.1681/ASN.2021040575
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Mediastinal fat associated lymphoid clusters: A novel immune structure controlling respiratory diseases and intrathoracic immune hemostasis. (2022)
  • Author(s): Y. H. A. Elewa, O. Ichii, S., Y. Kon
  • Organizer: The 5th international Conference of Medical Analysis, Toxins, and IVF”
  • Int'l Joint Research / Invited
• [Presentation] “Novel Fat Associated Lymphoid clusters with special focus on the CHICKEN AIR SACS AND MESENTERY: A HISTOMORPHOMETRICAL AND IMMUNOLOGICAL STUDY.” (2022)
  • Author(s): Y. H. A. Elewa, Md Rashedul Islam, Sherif Kh. A. Mohamed.
  • Organizer: The 17th College Scientific Conference of Faculty of Veterinary medicine, Zagazig University “Veterinary Medicine and One Health Concept”.
  • Int'l Joint Research / Invited
• [Remarks] Research map
  • URL: https://researchmap.jp/YaserElewa?lang=en