Memory-like ILC2 induction in Strongyloides venezuelensis infected mice

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K07469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49040:Parasitology-related
• Research Institution: Hyogo Medical University
• Principal Investigator: Yasuda Koubun 兵庫医科大学, 医学部, 講師 (50333539)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 訓練免疫 / 寄生虫感染防御 / IL-33 / TSLP

Outline of Final Research Achievements

ILC2 activation by IL-33 is essential for parasite species-nonspecific resistance to infection (trained immunity) after Strongyloides venezuelensis infection. We investigated the role of TSLP, which also activates ILC2, in protection against nematode infection and found that TSLP is also involved in CD4 T cell-independent protection in the early stages of infection. Similarly, no training effect was observed in RBBP9-deficient and IL-13-deficient mice, which are involved in IL-33 induction. These results suggest that induction of TSLP and IL-33 expression is important for memory ILC2 induction, which is critical for training immunity.

Free Research Field

寄生虫免疫

Academic Significance and Societal Importance of the Research Achievements

ILC2は感染免疫に貢献する一方でアレルギーなどの炎症性疾患でも増悪因子として働く。メモリー様ILC2は慢性アレルギー性疾患で関与すると考えられ、その誘導機序の解明は慢性アレルギー疾患の病態解明に重要である。本研究ではTSLPやRBBP9, IL-13などの因子が寄生虫感染による訓練免疫獲得に必須であることを見出したが、これらの因子はメモリー様ILC2誘導を介して慢性アレルギー疾患でも増悪に関与すると考えられ、新たなアレルギー性疾患御治療戦略の新たな標的となり得る。