2022 Fiscal Year Final Research Report
Analysis of glycolipid recognition mechanism in intestinal tissue invasion of Aeromonas and its application study
| Project/Area Number |
20K07504
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49050:Bacteriology-related
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Aeromonas / 腸管上皮 / 糖脂質 / 接着 |
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| Outline of Final Research Achievements |
The mechanism by which Aeromonas recognizes sphingoglycolipids (GSL) and causes infections is unknown. In this study, we investigated how Aeromonas recognizes GSL and contributes to infectious diseases by generating intestinal epithelial cells expressing glycans related to ABO blood groups and evaluating their interaction with Aeromonas. As a result, we identified strains of Aeromonas that recognize specific glycan structures and adhere to cells, and these bacteria were found to possess genes related to this glycan recognition. These findings offer insights that may contribute to a deeper understanding of infectious diseases and the development of innovative treatment methodologies.
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| Free Research Field |
細菌学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究はAeromonasがスフィンゴ糖脂質（GSL）を認識し感染症を引き起こす機構を明らかにした。特定のGSL構造を認識し細胞に接着するAeromonas株と、その関連遺伝子を同定した。これらの研究成果は感染症理解と新治療法開発のための重要な知見と考えられる。今後、得られた遺伝子の機能解析によりAeromonasの感染戦略の解明や新規治療ターゲットの探索に役立つものと期待される。
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