2023 Fiscal Year Annual Research Report
Elucidation of Natural Killer T cell development in a mice model of rheumatoid arthritis
| Project/Area Number |
20K07538
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| Research Institution | Osaka University |
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Principal Investigator |
ディエス ディエゴ 大阪大学, 免疫学フロンティア研究センター, 准教授 (90597741)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Immunology / Computational Biology / Bioinformatics |
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| Outline of Annual Research Achievements |
1. We have performed analysis of NKT development in SKG and WT BALB/c mice using single cell genomics (gene and protein expression, chromatin accessibility and immune repertoire). 2. We identify features (genes, proteins and regulatory regions) associated with different stages of differentiation, from double positive progenitors to mature naive NKT cell subtypes. 3. We find a putative novel TCR signature defining NKT cells. 4. Our results advance our understanding of the mechanisms of NKT development.
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