Functional analysis of glycoproteins in tumor spheres

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K07629
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Osaka International Cancer Institute
• Principal Investigator: Ohkawa Yuki 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 糖鎖オンコロジー部・研究員 (40723896)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 糖鎖 / がん / スフェロイド

Outline of Final Research Achievements

Fetuin-A: α-2-HS-glycoprotein, is secreted from the liver and can be detected in human blood. The function of Fetuin-A against cancer is not clear to date. In this study, we found that Fetuin-A increased cell growth rate and resistance in lung cancer cells against anti-cancer drug treatment. Additionally, we clarified a part of its molecular mechanisms.

Free Research Field

糖鎖生物学・腫瘍学

Academic Significance and Societal Importance of the Research Achievements

Fetuin-Aの癌に対する機能を世界に先駆けて明らかにした。またその作用メカニズムの一端を明らかにしたことから、Fetuin-Aを標的にした、新たな治療法の開発が期待される。