2022 Fiscal Year Annual Research Report
Development of novel tumor-targeting nanoparticles for malignant brain tumor neutron capture therapy and diagnosis
| Project/Area Number |
20K07672
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ザボロノク アレクサンドル 筑波大学, 医学医療系, 助教 (20723117)
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| Co-Investigator(Kenkyū-buntansha) |
中井 啓 筑波大学, 医学医療系, 准教授 (50436284)
鶴淵 隆夫 筑波大学, 医学医療系, 講師 (70778901)
MATHIS BRYAN 筑波大学, 附属病院, 病院講師 (80794635)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | BNCT / boron / gold / nanoparticles / tumor targeting |
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| Outline of Annual Research Achievements |
In the fiscal year 2022, still partly in the pandemic, we worked through a number of critical questions regarding the use of hybrid nanoparticles based on experimental data and tested the conditions of neutron irradiation experiments on a group of animals, resulting in a publication. Despite the effectiveness of nanoparticles in cell experiments, their practical use in animals was difficult. Since the polymer on the nanoparticles creates a surface layer that makes it difficult to bind to the tumor-targeting ApoB-29 molecules, on the other hand, the stability of the particles requires complete coverage of their surface, and using the particles without polymer stabilization leads to their aggregation. Based on the obtained results, it was decided to modify the nanoparticles and encapsulate the active components in a liposomal shell by bonding the targeting molecule to the gold component placed within the lipid bilayer. Neutron irradiation was performed with a previously approved compound to work out the irradiation technique close to clinical conditions. As a result, the principles of animal preparation and therapy were studied, including the methodology for calculating the radiation doses.
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Research Products
(6 results)
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[Presentation] 元素状ホウ素ナノ粒子を用いた加速器型BNCT実験2022
Author(s)
Zaboronok A、Khaptakhanova P、Uspenskii S、Bekarevich R、Mechetina L、Volkova O、Kanygin V、石川 栄一、Kasatova A、 Kasatov D、Shchudlo I、Sycheva T、Taskaev S、鶴淵 隆夫、松村 明
Organizer
第18回日本中性子捕捉療法学会学術大会, 2022-10-29 (茨城, つくば市)
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