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2022 Fiscal Year Annual Research Report

Development of novel tumor-targeting nanoparticles for malignant brain tumor neutron capture therapy and diagnosis

Research Project

Project/Area Number 20K07672
Research InstitutionUniversity of Tsukuba

Principal Investigator

ザボロノク アレクサンドル  筑波大学, 医学医療系, 助教 (20723117)

Co-Investigator(Kenkyū-buntansha) 中井 啓  筑波大学, 医学医療系, 准教授 (50436284)
鶴淵 隆夫  筑波大学, 医学医療系, 講師 (70778901)
MATHIS BRYAN  筑波大学, 附属病院, 病院講師 (80794635)
Project Period (FY) 2020-04-01 – 2023-03-31
KeywordsBNCT / boron / gold / nanoparticles / tumor targeting
Outline of Annual Research Achievements

In the fiscal year 2022, still partly in the pandemic, we worked through a number of critical questions regarding the use of hybrid nanoparticles based on experimental data and tested the conditions of neutron irradiation experiments on a group of animals, resulting in a publication. Despite the effectiveness of nanoparticles in cell experiments, their practical use in animals was difficult. Since the polymer on the nanoparticles creates a surface layer that makes it difficult to bind to the tumor-targeting ApoB-29 molecules, on the other hand, the stability of the particles requires complete coverage of their surface, and using the particles without polymer stabilization leads to their aggregation. Based on the obtained results, it was decided to modify the nanoparticles and encapsulate the active components in a liposomal shell by bonding the targeting molecule to the gold component placed within the lipid bilayer. Neutron irradiation was performed with a previously approved compound to work out the irradiation technique close to clinical conditions. As a result, the principles of animal preparation and therapy were studied, including the methodology for calculating the radiation doses.

  • Research Products

    (6 results)

All 2023 2022 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA2023

    • Author(s)
      Kanygin Vladimir、Zaboronok Alexander、Kichigin Aleksandr、Petrova Elena、Guselnikova Tatyana、Kozlov Andrey、Lukichev Dmitriy、Mathis Bryan J.、Taskaev Sergey
    • Journal Title

      Veterinary Sciences

      Volume: 10 Pages: 274~274

    • DOI

      10.3390/vetsci10040274

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 元素状ホウ素ナノ粒子を用いた加速器型BNCT実験2022

    • Author(s)
      Zaboronok A、Khaptakhanova P、Uspenskii S、Bekarevich R、Mechetina L、Volkova O、Kanygin V、石川 栄一、Kasatova A、 Kasatov D、Shchudlo I、Sycheva T、Taskaev S、鶴淵 隆夫、松村 明
    • Organizer
      第18回日本中性子捕捉療法学会学術大会, 2022-10-29 (茨城, つくば市)
  • [Presentation] 金ナノ粒子を用いた悪性腫瘍のホウ素中性子捕捉療法におけるin situ吸収線量評価.2022

    • Author(s)
      Zaboronok A、Taskaev S、Volkova O、Mechetina L、Kasatova A、Sycheva T、中井 啓、 Kasatov D、Makarov A、Shchudlo I、鶴淵 隆夫、Kanygin V、 Kichigin A、石川 栄一、松村 明
    • Organizer
      第18回日本中性子捕捉療法学会学術大会, 2022-10-29 (茨城, つくば市)
  • [Presentation] Boron neutron capture therapy (BNCT) as a malignant tumor radiotherapy method: Current state and development perspectives.2022

    • Author(s)
      Zaboronok Alexander
    • Organizer
      IV International Scientific Forum “Nuclear Science and Technologies, 2022.09.26-30 (Almaty, Kazakhstan)
    • Int'l Joint Research / Invited
  • [Remarks] 雑誌 Pharmaceutics (IF: 6.525) トピックアドバイザリーパネルメンバー

    • URL

      https://www.mdpi.com/journal/pharmaceutics/topical_advisory_panel

  • [Remarks] 雑誌 Pharmaceutics (IF: 6.525) 雑誌の特集号: ゲスト編集者

    • URL

      https://www.mdpi.com/journal/pharmaceutics/special_issues/nanoparticles_tumor

URL: 

Published: 2023-12-25  

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