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2022 Fiscal Year Final Research Report

Investigating the involvement of hemokinin-1 in the pruritus mechanism using optogenetics

Research Project

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Project/Area Number 20K07760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 51030:Pathophysiologic neuroscience-related
Research InstitutionUniversity of Miyazaki

Principal Investigator

Funahashi Hideki  宮崎大学, 医学部, 講師 (10404435)

Project Period (FY) 2020-04-01 – 2023-03-31
Keywordsitch / hemokinin-1 / mouse / tachykinin / optogenetics
Outline of Final Research Achievements

To elucidate the mechanism of itch, the AMPA receptor antagonist perampanel attenuates acute and chronic itch behavior (Haruta-Tsukamoto, Funahashi et.al. 2020), 5-HT3 receptor among serotonin receptors published that body and 5-HT7 receptors are associated with acute itch behavior of chloroquine and histamine in mice (Miyahara, Funahashi et.al. 2021). On the basis of these findings, we reported that the amygdala and parabrachial nucleus are involved in the control mechanism of itch by photogenetically manipulating the function of predynorphin (Funahashi, Pavlenko, Akiyama. 2023).

Free Research Field

palliative care

Academic Significance and Societal Importance of the Research Achievements

臨床的にかゆみは患者のQOLを低下させるが、決定的な治療法がなく、研究の発展や知見の積み重ねにより苦痛の緩和が強く望まれている。今回の研究ではヘモキニン-1のかゆみへの関与の解明には至らなかったが、その周辺であるAMPA受容体やセロトニン受容体、ダイノルフィン関連神経などの関与は明らかとなり、また光遺伝学による操作によって、より生体に近い形での研究手法が進展したことは、学術的にも社会的にも有益な結果であった。

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Published: 2024-01-30   Modified: 2025-03-27  

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