2022 Fiscal Year Final Research Report
Invesitgation of Eomes+ Th cells: a pathogenic population controlling neuroinflammation during secondary progressive multiple sclerosis
| Project/Area Number |
20K07775
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Raveney Benjamin 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 免疫研究部, 科研費研究員 (70795385)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Autoimmune disease / multiple sclerosis / neuroinflammation |
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| Outline of Final Research Achievements |
The autoimmune disease multiple sclerosis (MS) occurs when activated immune cells enter the brain and spine, causing tissue damage, which leads to peripheral and neurological disabilities. Previously, we found that a new type of T helper cell (Eomes+ Th cells) was associated with a model of chronic MS. In this study, we investigated how Eomes+ Th cells were associated with disease in patients with secondary progressive MS (SPMS), a chronic type of MS.
We found Eomes+ Th cells were increased in the blood of some patients with SPMS and these cells were infiltrating into patient brain tissue. Also, high levels of Eomes+ Th cells were associated with worsening clinical disease. This study highlights Eomes+ Th cell measurement as a biomarker for SPMS diagnosis and disease activity, allowing early treatment with efficacious drugs. As Eomes+ Th cells appear to be a pathogenic cell type associated with damage in SPMS, these cells are a candidate target for developing future SPMS treatments.
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| Free Research Field |
Autoimmune disease
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| Academic Significance and Societal Importance of the Research Achievements |
This study provides new information about a type of damage-associated T cells in autoimmune disease. This will aid future study of the process involving these cells and increase understanding of cellular immunology in diseased tissues as well as providing new biomarkers and targets for treatment.
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