2022 Fiscal Year Final Research Report
Elucidation of the mechanism of amyloid beta accumulation using novel anti-mutant amyloid beta antibody
| Project/Area Number |
20K07783
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 52010:General internal medicine-related
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | アミロイド / 神経病理 / 免疫染色 |
|---|
| Outline of Final Research Achievements |
Specific antibodies against the mutant amyloid were generated from the brains of patients of the D67N family with a familial Alzheimer's disease mutation. Using this antibody, immunostaining was performed on the brains of patients with the mutation, sporadic Alzheimer's disease, and age-related senile plaques. The results showed that the mutation-specific antibody bound only to amyloid in the brains of patients with the mutation, but not to sporadic cases or senile plaques associated with aging. This indicates that the mechanism of amyloid accumulation differs between familial and sporadic Alzheimer's disease.
|
| Free Research Field |
神経病理
|
| Academic Significance and Societal Importance of the Research Achievements |
本抗体が孤発性アルツハイマー病や加齢に伴うアミロイド沈着には結合せず，本変異特異的なアミロイド抗体であることが証明された．これにより，孤発例と家族性アルツハイマー病のアミロイド蓄積機序が異なることが示唆された．また，患者脳を検索する際に本抗体を用いることで本変異の有無を確認することができるようになった．
|
