心不全における腹部臓器血流と腸内細菌叢に関する検討

2020 Fiscal Year Research-status Report

• Project/Area Number: 20K07828
• Research Institution: Fukushima Medical University
• Principal Investigator: 義久 精臣 福島県立医科大学, 保健科学部, 教授 (40448642)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 心不全 / 腹部臓器血流

Outline of Annual Research Achievements

心不全における腹部臓器の血行動態(うっ血・低潅流)に関して検討した。成果について順次論文公表を行った。今後も継続して検討予定である。
具体的には、
1) 肝臓における肝静脈血流波形(CJC Open, in press), shear wave elastography (J Am Heart Assoc 2020; 9: e016689), shear wave dispersion (J Clin Med 2020; 9: 3953)の意義および病態に関して報告した。
2) 腎臓における腎静脈血流波形と低潅流の病態に関して報告した(Scientifc Reports 2020; 10:22257)。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

4編の論文公表を行い、継続して研究を行っている。

Strategy for Future Research Activity

継続検討課題に関して、今後論文投稿を行っていく予定である。

Research Products

• [Journal Article] Clinical Implications of Hepatic Hemodynamic Evaluation by Abdominal Ultrasonographic Imaging in Patients With Heart Failure (2020)
  • Author(s): Akiomi Yoshihisa, MD, PhD, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Yasuhiro Ichijo, MD, PhD, Yu Sato, MD, Tetsuro Yokokawa, MD, PhD, Tomofumi Misaka, MD, PhD, Masayoshi Oikawa, MD, PhD, Atsushi Kobayashi, MD, PhD, Takayoshi Yamaki, MD, PhD, Hiroyuki Kunii, MD, PhD, and Yasuchika Takeishi, MD, PhD.
  • Journal Title: J Am Heart Assoc Volume: 9 Pages: e016689
  • DOI: 10.1161/JAHA.120.016689.
  • Peer Reviewed / Open Access
• [Journal Article] Intrarenal Doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure (2020)
  • Author(s): Akiomi Yoshihisa, MD, PhD, Koichiro Watanabe, MD, Yu Sato, MD, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Yasuhiro Ichijo, MD, PhD, Tetsuro Yokokawa, MD, PhD, Tomofumi Misaka, MD, PhD, Masayoshi Oikawa, MD, PhD, Atsushi Kobayashi, MD, PhD, and Yasuchika Takeishi, MD, PhD.
  • Journal Title: Sci Rep Volume: 10 Pages: 22257
  • DOI: 10.1038/s41598-020-79351-6.
  • Peer Reviewed / Open Access
• [Journal Article] Shear Wave Dispersion Predicts Liver Fibrosis and Adverse Outcomes in Patients with Heart Failure (2020)
  • Author(s): Himika Ohara, Akiomi Yoshihisa, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Yukiko Sugawara, Yasuhiro Ichijo, Yu Hotsuki, Koichiro Watanabe, Fumiya Anzai, Yu Sato, Yusuke Kimishima, Tetsuro Yokokawa, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi and Yasuchika Takeishi.
  • Journal Title: J Clin Med Volume: 9 Pages: 3953
  • DOI: 10.3390/jcm9123953.
  • Peer Reviewed / Open Access
• [Presentation] Clinical implications of hepatic hemodynamic evaluation by abdominal ultrasonographic imaging in patients with heart failure. (2020)
  • Author(s): Hotsuki Y, Yoshihisa A, Ichijo Y, Watanabe K, Sato Y, Kimishima Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y.
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] Intrarenal doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure. (2020)
  • Author(s): Watanabe K, Yoshihisa A, Sato Y, Hotsuki Y, Ichijo Y, Kimishima Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y.
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] Liver dispersion predicts adverse outcomes in patients with heart failure. (2020)
  • Author(s): Hotsuki Y, Yoshihisa A, Watanabe K, Sato Y, Kimishima Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y.
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] 心不全患者の肝うっ血評価におけるshear wave elastographyの有用性に関する検討. (2020)
  • Author(s): 松田美津子, 山寺幸雄, 石橋伸治, 幕田倫子, 大沼秀知, 義久精臣, 志村浩己, 竹石恭知.
  • Organizer: 日本超音波医学会第93回学術集会
• [Presentation] Clinical implications of hepatic hemodynamic evaluation by ultrasonography in patients with heart failure. (2020)
  • Author(s): 寳槻 優, 義久精臣, 渡邊孝一郎, 佐藤 悠, 君島勇輔, 喜古崇豊, 菅野優紀, 横川哲朗, 阿部諭史, 三阪智史, 佐藤崇匡, 及川雅啓, 小林 淳, 竹石恭知.
  • Organizer: 第24回 日本心不全学会学術集会
• [Presentation] Intrarenal doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure. (2020)
  • Author(s): 渡邊孝一郎, 佐藤 悠, 義久精臣, 一條靖洋, 寳槻 優, 横川哲朗, 三阪智史, 及川雅啓, 小林 淳, 竹石恭知.
  • Organizer: 第24回 日本心不全学会学術集会
• [Remarks] 福島県立医科大学 研究者データベース
  • URL: https://www.fmu.ac.jp/kenkyu/html/725_ja.html