心不全における腹部臓器血流と腸内細菌叢に関する検討

2022 Fiscal Year Annual Research Report

• Project/Area Number: 20K07828
• Research Institution: Fukushima Medical University
• Principal Investigator: 義久 精臣 福島県立医科大学, 保健科学部, 教授 (40448642)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 心不全 / 腹部臓器血流 / 肝障害 / 腎障害 / 消化管障害

Outline of Annual Research Achievements

肝臓や腎臓におけるうっ血と低灌流について腹部エコーを用いて評価する手法を確立した
(Sci Rep 10, e22257, 2020; J Am Heart Assoc 9, e016689, 2020; Front Cardiovasc Med 9, 772466, 2022; CJC Open 3, 778-86, 2021; J Clin Med 9, 3953, 2020)。上記論文にて、右心カテーテルによる右房圧と腹部エコーによる肝硬化指数shear wave
elastography (SWE)値の関係、心拍出量と腹腔動脈・腸間膜動脈・腎動脈血流の関係を検討し、それぞれ相関を認めることを報告した。また、肝臓や腎臓のうっ血、低灌流を認める症例では予後が不良であった。さらに、肝静脈血流波形や腎静脈血流波形が臓器うっ血を反映した(CJC Open 3, 778-86,2021)。さらに、心不全患者では肝臓の低灌流によりヘパトカインであるSelenoprotein Pの上昇やFetuin-Aの低下を認め不良な予後と関連しており、心肝連関の１つの機序として注目した（Clin Res Cardiol, in press; J Am Heart Assoc 11, e024901, 2022）。また、消化管障害の存在にて、心不全予後が悪化することなどについても公表した(Eur J Prev Cardiol 27, 664-6, 2020)。

Research Products

• [Journal Article] Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure (2023)
  • Author(s): Nozaki Yuji、Yoshihisa Akiomi、Sato Yu、Ohara Himika、Sugawara Yukiko、Abe Satoshi、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: Journal of Clinical Medicine Volume: 12 Pages: 1257～1257
  • DOI: 10.3390/jcm12041257
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of spleen shear wave elastography and dispersion in patients with heart failure: the crucial role of cardio-splenic axis (2023)
  • Author(s): Tomofumi Misaka, Akiomi Yoshihisa, Yasuhiro Ichijo, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Himika Ohara, Yukiko Sugawara, Fumiya Anzai, Yu Sato, Satoshi Abe, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Yasuchika Takeishi
  • Journal Title: Clin Res Cardiol Volume: N.A. Pages: in press
  • DOI: 10.1007/s00392-023-02183-7.
  • Peer Reviewed
• [Journal Article] Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure (2022)
  • Author(s): Ryohei Takeishi, Tomofumi Misaka, Yasuhiro Ichijo, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Himika Ohara, Yukiko Sugawara, Yu Hotsuki, Koichiro Watanabe, Fumiya Anzai, Yu Sato, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Akiomi Yoshihisa, Yasuchika Takeishi
  • Journal Title: J Am Heart Assoc Volume: 11 Pages: e024901
  • DOI: 10.1161/JAHA.121.024901.
  • Peer Reviewed / Open Access
• [Journal Article] Decreases in hepatokine Fetuin-A levels are associated with hepatic hypoperfusion and predict cardiac outcomes in patients with heart failure (2022)
  • Author(s): Tomita Yusuke、Misaka Tomofumi、Yoshihisa Akiomi、Ichijo Yasuhiro、Ishibashi Shinji、Matsuda Mitsuko、Yamadera Yukio、Ohara Himika、Sugawara Yukiko、Hotsuki Yu、Watanabe Koichiro、Anzai Fumiya、Sato Yu、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Takeishi Yasuchika
  • Journal Title: Clinical Research in Cardiology Volume: 111 Pages: 1104-1112
  • DOI: 10.1007/s00392-022-02023-0
  • Peer Reviewed
• [Journal Article] Prognostic Effects of Changes in Right Ventricular Fractional Area Change in Patients With Heart Failure (2022)
  • Author(s): Yukiko Sugawara, Akiomi Yoshihisa, Ryohei Takeishi, Himika Ohara, Fumiya Anzai, Yu Hotsuki, Koichiro Watanabe, Yu Sato, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atushi Kobayashi, Kazuhiko Nakazato, Yasuhicka Takeishi
  • Journal Title: Circ J Volume: 86 Pages: 1982-1989
  • DOI: 10.1253/circj.CJ-22-0212.
  • Peer Reviewed / Open Access
• [Journal Article] Impaired brain activity in patients with persistent atrial fibrillation assessed by near-infrared spectroscopy and its changes after catheter ablation (2022)
  • Author(s): Yoshihisa Akiomi、Kono Soichi、Kaneshiro Takashi、Ichijo Yasuhiro、Misaka Tomofumi、Yamada Shinya、Oikawa Masayoshi、Miura Itaru、Yabe Hirooki、Takeishi Yasuchika
  • Journal Title: Scientific Reports Volume: 12 Pages: 7866
  • DOI: 10.1038/s41598-022-12097-5
• [Journal Article] Renal Venous Stasis Index Reflects Renal Congestion and Predicts Adverse Outcomes in Patients With Heart Failure (2022)
  • Author(s): Ohara Himika、Yoshihisa Akiomi、Horikoshi Yuko、Ishibashi Shinji、Matsuda Mitsuko、Yamadera Yukio、Sugawara Yukiko、Ichijo Yasuhiro、Hotsuki Yu、Watanabe Koichiro、Sato Yu、Misaka Tomofumi、Kaneshiro Takashi、Oikawa Masayoshi、Kobayashi Atsushi、Takeishi Yasuchika
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 9 Pages: 772466
  • DOI: 10.3389/fcvm.2022.772466
• [Journal Article] B-type natriuretic peptide is associated with the occurrence of bleeding events in heart failure patients with a history of coronary artery disease (2022)
  • Author(s): Sato Yu、Yoshihisa Akiomi、Takeishi Ryohei、Ohara Himika、Sugawara Yukiko、Ichijo Yasuhiro、Hotsuki Yu、Watanabe Koichiro、Abe Satoshi、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: Journal of Cardiology Volume: 80 Pages: 88～93
  • DOI: 10.1016/j.jjcc.2022.02.003
• [Remarks] 福島県立医科大学 研究者データベース 義久精臣
  • URL: https://www.fmu.ac.jp/kenkyu/html/725_ja.html
• [Remarks] 福島県立医科大学 循環器内科学講座 心不全臨床研究
  • URL: https://www.fmu.ac.jp/home/int-med1/reserch-c-hf.htm