The effects of exercise on body composition and lipoprotein lipase in middle-aged people

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K07841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Gunma University
• Principal Investigator: Kimura Takao 群馬大学, 大学院医学系研究科, 准教授 (90396656)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: exercise / lipid metabolism / lipoprotein lipase / glucose metabolism / aging

Outline of Final Research Achievements

28 people were enrolled as participants in this study, and 13 completed the exercise volume for 6 months. Exercise therapy was performed under the guidance of a health exercise instructor at an exercise-type health promotion facility certified by the Minister of Health, Labor and Welfare. Exercise reduced body fat and increased skeletal muscle mass. Markers of glucose metabolism and lipid metabolism tended to decrease after exercise, but there was no statistically significant difference. Lipoprotein lipase (LPL) and adiponectin tended to increase after exercise, but no significant difference was observed. Fat mass decreased and skeletal muscle mass increased regardless of the amount of exercise during the 6-month exercise regimen. We are continuing to analyze the relationship between changes in blood glucose metabolism and lipid metabolism markers and the amount of exercise during exercise therapy.

Free Research Field

lipid metabolism

Academic Significance and Societal Importance of the Research Achievements

国内では急速に進行する高齢化と動脈硬化性疾患の増加への対応が喫緊の課題である。本研究は中高年者を対象とした運動療法が糖・脂質代謝に与える影響を明らかにすることが目的である。60歳前後の女性が週に1回以上、運動療法施設で健康運動指導士の指導の下、有酸素運動とレジスタンス運動を6か月間実施することで体脂肪が減少し、骨格筋量が増えることが明らかになった。血中の脂質・糖代謝マーカーの変化と運動量との関係については統計学的な変化を認めるには一定以上の運動量が必要と考えられる。本研究成果により個人レベルで糖・脂質代謝改善目的に必要な運動量がどのようなものかを明らかにし、社会の健康増進への貢献が期待できる。