2023 Fiscal Year Final Research Report
Clinical laboratory test using samples self-collected at home by ultra-high sensitivity ELISA for online medical consultation
| Project/Area Number |
20K07848
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋田 誠一 愛媛大学, 医学部, 研究員 (10156268)
高門 美沙季 愛媛大学, 医学部附属病院, 助教 (30838032)
池田 陽介 愛媛大学, 医学部附属病院, 助教 (60866698)
大澤 春彦 愛媛大学, 医学系研究科, 教授 (90294800)
川村 良一 愛媛大学, 医学系研究科, 講師 (90533092)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 高感度測定系 / 在宅 / スクリーニング / メタボリック症候群 / 歯周病 |
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| Outline of Final Research Achievements |
The purpose of this research is to analyze the usefulness of clinical laboratory test using samples self-collected non-invasively at home, such as urine and saliva by an ultrasensitive ELISA system for early detection of common disease. 1) Screening of metabolic syndrome (Mets) and insulin resistance using urine sample-collected at home. We measured soluble insulin receptor (sIR) levels in morning urine using a highly sensitive ELISA system. We found urinary sIR levels were associated with HOMA2IR and HOMA2S. Further, urinary sIR levels were increased in subjects with metabolic syndrome. 2) Screening for periodontal disease (PD) using saliva collected at home. Protein X levels in saliva were positively correlated with hemoglobin and LD concentrations and periodontal pocket depth. X levels were increased in diabetic subjects with PD.These approaches to people who have not received a medical examination, may prompt behavior modification and it may lead to early medical intervention.
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| Free Research Field |
臨床検査医学
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| Academic Significance and Societal Importance of the Research Achievements |
今後本邦において、オンライン診療が進んでいくと考えられるが、その課題として、血液検査のような臨床検査を受けることができないことがあげられる。また、特に働き盛りの世代の健診や歯科健診の未受診も問題である。そこで、在宅で採取された尿、唾液、指尖全血をろ紙に採取したものなどの郵送検査により疾患の早期スクリーニングができれば、受診すべき対象の絞り込みや行動変容、早期治療につながることが期待できる。本研究の成果により、在宅で非侵襲的に採取されたサンプルによる疾患スクリーニングを行う新しい臨床検査システムの有用性を示すことができた。
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