2022 Fiscal Year Final Research Report
Study on the assessment of odor identification as the screening test for early diagnosis of dementia
| Project/Area Number |
20K07849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
奥谷 文乃 高知大学, 教育研究部医療学系看護学部門, 教授 (10194490)
上村 直人 高知大学, 教育研究部医療学系臨床医学部門, 准教授 (10315004)
米田 哲也 熊本大学, 大学院生命科学研究部(保), 准教授 (20305022)
数井 裕光 高知大学, 教育研究部医療学系臨床医学部門, 教授 (30346217)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | アルツハイマー型認知症 / 軽度認知障害 / 嗅覚障害 / 統計画像解析 |
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| Outline of Final Research Achievements |
Alzheimer's disease (AD) has been shown to cause olfactory impairment from the early stages of the disease.
Mild cognitive impairment (MCI), which has been proposed as a precursor condition to AD, may include diseases other than AD, as some cases remain in MCI for a long time or recover normally. We hypothesized that the presence of olfactory impairment in MCI is a potential non-invasive biomarker for the development of AD. We investigated the neural basis of olfactory dysfunction in MCI to early AD and the transition from MCI to AD and olfactory dysfunction in MCI to AD. Statistical imaging analysis revealed that the olfactory detection and identification are correlated in MCI and AD, respectively, and that the detection zone is preserved in MCI, whereas the cognitive zone is injured, resulting in a high frequency of AD.
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| Free Research Field |
老年精神医学
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| Academic Significance and Societal Importance of the Research Achievements |
認知症に対する早期に治療介入、予防という観点から、MCIからADへの移行を予測できる因子の開発は重要である。MCIから初期ADにおける嗅覚低下の神経基盤を解明し、MCI段階での嗅覚障害パターンを明らかにすることで、嗅覚検査がAD 移行への非侵襲的バイオマーカーとして活用される展望が与えられる。我々の研究では、神経基盤に加え、嗅覚障害の程度による2年間のADへの移行率を示すことができ、学術的、社会的に有意義な研究であった。
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