2022 Fiscal Year Final Research Report
Neuropsychological and neuroradiorodical examination in amyotrophic lateral sclerosis (including language evaluation))
| Project/Area Number |
20K07867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 筋萎縮性側索硬化症 / 前頭側頭型認知症 / 原発性進行性失語症 |
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| Outline of Final Research Achievements |
In this study, we conducted 10 types of language tests on 115 cases based on the diagnostic criteria for primary progressive aphasia (PPA). We compared four groups of patients with neurodegenerative diseases, namely ALS, PD, AD, and PSP, with a control group. As a result, we found characteristic patterns of language impairment in each group. Moreover, the 10 items of the screener showed high discriminative power, except for the PSP group.
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| Free Research Field |
脳神経内科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は比較的簡便に神経変性疾患（PPA，FTD, ALS, AD, PD, PSP,等）を含めた神経変性疾患における言語機能を評価できる可能性がある．さらに疾患による言語の特徴を描出できる可能性も示唆された．検査自体は今後オンディマンドでの実施によりより簡便になりうる．
論文発表やホームページに掲載することにより本検査法を全国的に周知することにより，変性疾患による異常の早期発見にも寄与すると考えられる．
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