2022 Fiscal Year Final Research Report
Effects of negative symptoms including impairment in goal generation process and social cognitive function on social function in patients with Schizophrenia
| Project/Area Number |
20K07913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
豊巻 敦人 北海道大学, 大学病院, 助教 (70515494)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 統合失調症 / 陰性症状 / 強化学習 / コストベネフィット分析 / EBDM課題 / RBL課題 |
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| Outline of Final Research Achievements |
The EBDM task was examined in 41 patients with schizophrenia and 12 healthy subjects. In a mixed-effects model with the choice of high-load task as the dependent variable, reward amount, reward probability, diagnosis, and their interactions as fixed effects and subjects as random effects, we found main effects of reward amount and reward probability and interactions between reward amount and reward probability, but no main effect of diagnosis or interactions between diagnosis and reward or reward probability. For the RBL task, 48 schizophrenic patients and 19 healthy controls were compared. In the task to determine which of the paired symbols had a higher probability of success, the rate of correct responses for the easiest task was significantly lower in the patient group. The rate of correct responses to the hardest pair was significantly correlated with disorganization symptoms and social functioning in the schizophrenic patients.
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| Free Research Field |
認知機能障害
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| Academic Significance and Societal Importance of the Research Achievements |
統合失調症は人口の0.3-0.7%が罹患する頻度の高い疾患であるが、多くの患者は就労、就学の継続が困難であり、社会機能の改善が大きな課題となっている。統合失調症では、幻覚や妄想などの陽性症状と比較して、陰性症状と認知機能障害が社会機能により強く影響することが知られている。我々は陰性症状の生物学的基盤と考えられている強化学習の障害とコストベネフィット分析の障害を評価する課題を行い、強化学習の障害を評価するRBL課題の成績が認知機能障害および社会機能の障害と相関することを見出した。本研究から強化学習の障害の評価および、障害を改善するアプローチが患者の社会機能を改善する可能性が示唆された。
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