2023 Fiscal Year Final Research Report

Research on personalized medicine for depression using a portable sleep electroencephalograph

Research Project

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Project/Area Number	20K07956
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52030:Psychiatry-related
Research Institution	Nihon University
Principal Investigator	SUZUKI Masahiro 日本大学, 医学部, 教授 (20526107)
Co-Investigator(Kenkyū-buntansha)	谷口哲也日本大学, 医学部, 准教授 (10383556) 横瀬宏美日本大学, 医学部, 助教 (40465274) 金子宜之日本大学, 医学部, 准教授 (50774147) 斎藤かおり日本大学, 医学部, 助手 (60838902) 久保英之日本大学, 医学部, 助教 (70451367)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	うつ病 / 睡眠
Outline of Final Research Achievements	The usefulness of a portable sleep electroencephalograph in clinical practice for depression was examined. Patients who responded to depression treatment showed shorter sleep latency and a shorter rapid eye movement (REM) sleep period than those who did not respond. In addition, beta activity during REM sleep was lower in patients who responded. Analyses using existing data suggest that the association between subjective insomnia and depressive symptoms is a transdiagnostic feature of major psychiatric disorders, and that nonrestorative sleep could be a useful indicator for predicting incident depression and assessing suicide risk.
Free Research Field	精神医学
Academic Significance and Societal Importance of the Research Achievements	ポータブル睡眠脳波計で取得した睡眠脳波情報が、うつ病の治療反応予測に利用できる可能性が示唆された。主要な精神疾患において、主観的不眠が抑うつ症状と関連することが明らかとなった。睡眠の質を表す「睡眠休養感」に着目することによって、より有効なうつ病予防や自殺予防が実践できる可能性が示唆された。