2022 Fiscal Year Final Research Report
Central mechanisms for continuous responses of sympathetic nervous system to stress exposure
| Project/Area Number |
20K07982
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡田 尚志郎 愛知医科大学, 医学部, 教授 (40203989)
呉 ユー秋 愛知医科大学, 医学部, 助教 (40717154)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | ストレス / 交感神経系 / カテコールアミン / 視床下部室傍核 |
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| Outline of Final Research Achievements |
Stress exposure causes various stress responses including sympathetic activation. Continuous stress responses are one of risk factors associated with stress-related diseases such as depression. We have already reported that corticotropin-releasing factor (CRF) in the brain is important for continuous sympathetic activation, and that brain prostanoids are related to CRF-induced sympathetic activation.
In this study, we examined the mechanisms in the brain, especially in the paraventricular hypothalamic nucleus (PVN), of sympathetic activation during acute and repeated exposure to stress. Our results demonstrated that sympathetic responses during chronic stress exposure were different from those in acute stress, and that brain prostanoids were associated with such differences.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
ストレス反応は本来、生体の防御機構である。しかし、過剰なストレス反応はストレス不適応をもたらし、さらにはうつ病などのストレス関連疾患の発症の契機ともなりうる。このような過剰かつ持続するストレス反応をもたらす脳内の調節機構については、交感神経反応制御の観点では未だ不明な点も多い。
本研究の成果から、ストレス強度による交感神経反応の違いや脳内調節に関与する因子についての知見が得られた。ストレス応答の調節メカニズムに関する基礎的知見蓄積の一助となり、将来的にストレス関連疾患の予防・治療法の開発に繋がると考えられる。
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