Comprehensive Assessment of Early Diabetic Nephropathy using Functional MR Imaging and Development of Novel Diagnostic Approaches.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kawasaki Medical School
• Principal Investigator: Yamamoto Akira 川崎医科大学, 医学部, 准教授 (30319959)
• Co-Investigator(Kenkyū-buntansha): 玉田 勉 川崎医科大学, 医学部, 教授 (40278932) ; 檜垣 篤 川崎医科大学, 医学部, 講師 (90454850)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 糖尿病性腎症 / MRI / 機能的MRI

Outline of Final Research Achievements

Functional MR imaging was performed on a total of 122 subjects, including 99 diabetic patients and 23 healthy individuals, and 21 parameters were calculated. These parameters were compared between the early diabetic nephropathy group and the healthy group, significant differences were observed in two parameters: the T2 value and the corticomedullary differentiation by optimal TI on SSFP with IR pulse. Both parameters were considered sensitive indicators of increased water content in the renal cortex associated with glomerular hypertension in early diabetic nephropathy. These findings suggest that these parameters may be useful in diagnosing early diabetic nephropathy.

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

糖尿病性腎症は血液透析導入の原疾患として最も多い疾患である。また心筋梗塞や脳梗塞などの心血管イベント発生の増加をもたらす。糖尿病性腎症は早期において適切な治療を行うことで進行の抑制や治癒が可能とされている。MRIは非侵襲的検査で、被ばくを伴わないため、健康診断などのスクリーニング検査にも応用できる可能性があり、現状の糖尿病性腎症の診断の検査項目に加えることで、より早期の糖尿病性腎症の検出が可能となる可能性があり、そうなれば透析患者数の減少、ひいては医療経済に貢献する可能性があると考えている。