2023 Fiscal Year Final Research Report
Establishment of non-invasive image assessment method for early detection and therapeutic effect determination of pulmonary hypertension by ultra-high-resolution computed tomography
| Project/Area Number |
20K08048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
酒井 宏 滋賀医科大学, 医学部, 講師 (00595100)
仲川 宏昭 滋賀医科大学, 医学部, 助教 (70799478)
中山 良平 立命館大学, 理工学部, 教授 (20402688)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 肺高血圧症 / 超高精細CT / 膠原病関連間質性肺炎 |
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| Outline of Final Research Achievements |
Normal-resolution simulated images (NRsim) were generated based on super high-resolution (SHR)images obtained in clinical examinations in 11 pulmonary hypertension (PH), 9 connective tissue disease-related interstitial lung disease without PD(CTD-IP), and 11 control subjects(CS). By using binarized image data with a threshold of -720 HU, the percentage of the cross-sectional area of pulmonary small vessel area (%CSA) and average vessel dimension(AVD) for pulmonary small vessels with 0 to 5 mm2 were measured in the predefined three trans-axial planes including the aortic arch, tracheal bifurcation and the orifice of the right pulmonary inferior vein. On SHR images, %CSA of 2 to 5 mm2 in PH tended to be smaller than CTD-IP, in addition, AVD of 0 to 2 mm2 in PH was smaller as compared with CS, and demonstrated to have a negative strong correlation with systolic as well as mean pulmonary artery pressure. In contrast, no significant association was found on NRsim images.
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| Free Research Field |
胸部画像診断
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| Academic Significance and Societal Importance of the Research Achievements |
一般的な胸部CTの際の放射線被曝（約9.4mSv）を下回る線量下の超高精細CTでえられた胸部CTデータの最適な二値化画像での平均血管断面積が、対照群と比較し、肺高血圧症で小さく、肺高血圧症が中等度・高度となるにつれて小さくなったという結果は、非侵襲的な診断モダリティーである超高精細CTが、肺野微小動脈のリモデリングを直接的に評価できる可能性を示したものであり、非常に有用と考えられる。肺高血圧症多岐にわたる病因から生じる病態であるため、今後さらなる症例の蓄積により、確立された評価指標となれば、臨床的な意義は非常に高いと考えられる。
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