Development of Predictive Biomarkers for Postoperative Acute Exacerbation in Lung Cancer Complicated by Interstitial Pneumonia Using PET Texture Analysis

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kagawa University
• Principal Investigator: Murota Makiko 香川大学, 医学部附属病院, 講師 (90437666)
• Co-Investigator(Kenkyū-buntansha): 久冨 信之 香川大学, 医学部, 准教授 (20552045) ; 山本 由佳 香川大学, 医学部, 准教授 (30335872) ; 西山 佳宏 香川大学, 医学部, 教授 (50263900) ; 石村 茉莉子 香川大学, 医学部附属病院, 助教 (60730348)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: PET / CT / 間質性肺炎 / 肺癌 / 術後急性増悪

Outline of Final Research Achievements

In patients with lung cancer complicated by interstitial pneumonia, one of the risk factors for acute exacerbation of interstitial pneumonia is the UIP pattern on CT. In this study, we devised an analysis method, considering whether FDG-PET/CT examination, routinely performed as preoperative evaluation for lung cancer, could also serve as an indicator of acute exacerbation.
In this study, we observed the interstitial pneumonia pattern on chest CT, FDG accumulation index on F-FDG PET/CT, clinical indicators, and the presence of acute exacerbation of interstitial pneumonia in preoperative examinations of lung cancer complicated by interstitial pneumonia. We observed a correlation between SUV values and %Dlco, but no correlation was found between fractal dimension and clinical indicators. Acute exacerbation was observed in only one case, making detailed investigation difficult.

Free Research Field

放射線診断学

Academic Significance and Societal Importance of the Research Achievements

本研究では胸部CTでの間質性肺炎UIPパターンにおけるFDG PET/CTのSUV値と%DLcoが相関することが観察され、臨床的指標の予測に有用であることが示唆された。間質性肺炎のFDG-PET集積におけるフラクタル解析を行ったのは初の試みであり、より高次のテクスチャ解析を進める足掛かりとなると考える。