Quantitative evaluation of cerebral blood flow measured by Hadamard encoded ASL

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: University of Fukui
• Principal Investigator: Isozaki Makoto 福井大学, 学術研究院医学系部門(附属病院部), 講師 (60464054)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脳循環評価 / Arterial Spin Labeling / PET/MRI

Outline of Final Research Achievements

15O-water PET and Hadamard encoded ASL were performed using PET/MRI equipment, and cerebral blood flow (CBF), arterial transit time (ATT), and cerebral vascular reactivity (CVR) due to acetazolamide load were measured. Correlation analysis of each showed a statistically significant correlation between the data obtained by PET and ASL for CBF. CVR and ATT also showed a significant inverse correlation. Evaluation of CBF and ATT using MRI is strongly correlated with CBF and CVR measured by conventional nuclear medicine examination, suggesting that in the future it will be possible to evaluate cerebral circulation by non-exposure and minimally invasive MRI examination. was done.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

虚血性脳血管障害の脳循環評価は、現在SPECT、PETといった核医学検査によって行われている。本研究ではMRIを用いた新しい脳循環検査法(Hadamard encoded ASL法)で得られたCBF、ATTはPETで得られたCBFおよびアセタゾラミド負荷によって得られたCVRと強く相関していることが証明された。これはMRIという被曝せずに薬剤も使わずに行える検査が今後の脳循環評価のスタンダードになりえる可能性を示唆する結果である。より低侵襲な検査法の開発であり、臨床診療における意義は大きいと考える。