2023 Fiscal Year Final Research Report
Clinical study to develop the novel therapy for decompensated liver cirrhosis combinede with interventional radiology and liver regeneration
| Project/Area Number |
20K08137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 非代償性肝硬変 / IVR治療 / 肝再生 |
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| Outline of Final Research Achievements |
Development of portosystemic shunts has been reported to be one of prognostic factors in patients with liver cirrhosis with portal hypertension. The aim of this clinical research is to elucidate the impact of portosystemic shunt occlusion on hepatic fibrosis and cross-talk between liver and lung. The present study demonstrated that balloon-occluded retrograde transvenous obliteration could result in increased portal venous flow and elevated nitrogen oxide levels, leading to an improvement in hepatic fibrosis. In addition, from the results of this study, the procedure might be a therapeutic option for portopulmonary hypertension through the correction of pulmonary hemodynamics related to the regulation of both systemic hemodynamics and humoral substances by portosystemic shunt occlusion.
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| Free Research Field |
肝硬変・門脈圧亢進症
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| Academic Significance and Societal Importance of the Research Achievements |
門脈-大循環シャント(PSS)は、肝臓を介することなく門脈血流を大循環に流出させる異常血管であり、肝循環のみならず全身循環にも影響を及ぼし得る。従ってバルーン閉塞下逆行性経静脈的塞栓術(BRTO)によるPSS閉塞は、肝機能や肝線維化の改善のみならず、全身循環障害の是正による他臓器の機能改善をもたらすことが予想される。PSS合併症例においてBRTOが肝線維化および肝肺連関に及ぼす影響に関する報告は未だなく、その未知なる付随効果を証明することで非代償性肝硬変患者の予後延長につながる新規治療戦略の構築が期待できる。従って、本研究の学術的意義ならびに社会的意義は大きいものと自己評価する。
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