2023 Fiscal Year Final Research Report
Development of Novel IVR Therapy by Integrating Nanotechnology and Molecular Imaging Technology
| Project/Area Number |
20K08141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Interventional radiology / 分子イメージング / 肝腫瘍モデル |
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| Outline of Final Research Achievements |
Using a rat model of hepatocellular carcinoma, we investigated the relationship between the abnormal vascular architecture into tumors induced by anti-VEGF drugs and VEGF concentration. Pathological specimens were prepared and are currently being evaluated for abnormal vessel construction. Ultrasound elastography technique was applied to confirm the changes in hardness and stromal pressure within the tumor.
In the current study, we investigated whether changes in tumor hardness occur with the duration of medication, keeping the concentration of anti-VEGF drugs constant. When the concentration was kept constant, a significant difference in hardness occurred around day 4 of the dosing period. In the future, we plan to investigate the activation of FGFR in tumors.
We are also currently adjusting the dosage and duration of anti-VEGF drugs to determine their effect on arterial embolization.
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| Free Research Field |
Interventional radiology
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| Academic Significance and Societal Importance of the Research Achievements |
これまで培った小動物への腫瘍モデル作成、薬物療法と画像診断機器を応用したイメージング技術を融合できたことは今回の成果の一つである。また、IVR治療をこれらの背景に適応させることで、新規IVR治療の開発につながると考える。現在は、動物レベルではあるが、IVR治療の有効性について組織学的病理学的に評価しており、それらを示すことができれば、ヒトへの安全性評価につながると予想される。
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