2020 Fiscal Year Research-status Report
Development of a technique to noninvasively study the structure of in vivo vasculature in rodent brain using oscillating-gradient spin-echo diffusion-weighted magnetic resonance imaging
| Project/Area Number |
20K08150
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Jeffrey Kershaw 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 主任研究員(任常) (50508801)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | OGSE / diffusion-weighted MRI / frequency domain / asymptotic behaviour |
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| Outline of Annual Research Achievements |
Most of our effort during the first year was aimed at clarifying how oscillating-gradient spin-echo diffusion-weighted MRI (OGSE-DWI) measurements should be interpreted. A manuscript was submitted to and accepted by the Journal of Magnetic Resonance. In the article we demonstrated that practical restrictions on the duration and number of oscillations of a real motion-probing gradient means that the technique has limited spectral resolution and range. A new signal equation was derived that naturally incorporates these restrictions, and it was found that there are several aspects of the new framework that distinguish it from the signal model conventionally used to analyse OGSE-DWI data.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Although important progress has been made in preparing and publishing one article, we must say that we are not as far advanced as hoped. As well as the restrictions placed on us due to the COVID-19 pandemic, the reason for this is that revisions of our first manuscript were unexpectedly time-consuming. A difference of opinion with one of the reviewers of the manuscript on one small issue meant that four rounds of revision were required. Happily, the issue was finally resolved, and the paper was accepted.
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| Strategy for Future Research Activity |
Rather than moving directly on to the experimental component of the project, we have decided for the moment to continue developing our new signal framework for OGSE-DWI. The simple reason for this is the need for a rigorous method for analysing the data when it is eventually acquired. The present focus of our work is on the asymptotic high- and low-frequency limits of the signal. A second manuscript based on this work is in the advanced stages of preparation.
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| Causes of Carryover |
Due to the COVID-19 pandemic we have been unable to attend several conferences and the corresponding registration fees have therefore accrued.
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