2022 Fiscal Year Research-status Report
Development of a technique to noninvasively study the structure of in vivo vasculature in rodent brain using oscillating-gradient spin-echo diffusion-weighted magnetic resonance imaging
| Project/Area Number |
20K08150
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| Research Institution | National Institutes for Quantum Science and Technology |
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Principal Investigator |
Jeffrey Kershaw 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 分子イメージング診断治療研究部, 主任研究員 (50508801)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | OGSE / diffusion-weighted MRI / frequency domain / asymptotic behaviour / structural universality |
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| Outline of Annual Research Achievements |
Our efforts over the past year include continued revision and other activity towards the publication of our second manuscript, which focusses on understanding the asymptotic high- and low-frequency limits of the signal when measured with OGSE-DWI. Based on the results in this manuscript a presentation was made at the ISMRM Japan Chapter meeting in Nagoya (Sept 10-11, 2022).
We have also extended our work on the ADC measured with OGSE-DWI. In particular, it has been demonstrated that the dynamic exponent characterising the global organisation of a medium may be systematically underestimated. This fact will be the core result in a presentation to be made at the ISMRM conference in Toronto in June 2023.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Unfortunately, even though we have submitted our second manuscript to five different journals it has not yet been accepted for publication. As we understand it, the problem is not the quality or correctness of the work, but the highly technical nature of the contents and its suitability to the targeted journals. On the one hand, after submitting to a physics or specialist MR imaging journal we have been told that the work would be more suitable for an applied mathematics journal. However, after submitting to such a journal we have told the exact opposite; that is, the work should be submitted to a physics or specialist MR imaging journal. It has been quite frustrating, but we shall continue searching for a suitable journal.
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| Strategy for Future Research Activity |
Work continues on the preparation of a third manuscript where we generalise the results of our OGSE-DWI papers to any DWI sequence. This work will enable the results of asymptotic measurements from experiments using different DWI sequences to be compared. We hope to be able to submit it to the Journal of Magnetic Resonance sometime later this year.
Beyond the third manuscript, we plan to extend our work to better understand the relationship between gradient parameters and the spatial aspects (eg. field-of-view, voxel size) of the signal in the asymptotic limits. Such a generalisation may be important for anisotropic media like brain tissue.
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| Causes of Carryover |
Due to the COVID-19 pandemic we have been unable to attend several conferences and the corresponding travel and registration fees have therefore accrued.
Also, funds for experimental work have been unnecessary as the work has concentrated on theoretical developments over the last year.
Costs in the next year will cover travel and registration fees for conferences in Toronto, Canada and Karuizawa.
Fees for open access publication may also be incurred.
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