Effects of salivary secretion on the development of gastroesophageal reflux disease, including PPI-resistant reflux esophagitis

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Nippon Medical School
• Principal Investigator: Iwakiri Katsuhiko 日本医科大学, 大学院医学研究科, 大学院教授 (50221099)
• Co-Investigator(Kenkyū-buntansha): 辰口 篤志 日本医科大学, 医学部, 准教授 (10350125) ; 北迫 勇一 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (30361702)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 逆流性食道炎 / 重症逆流性食道炎 / 軽症逆流性食道炎 / 非びらん性逆流症 / 唾液分泌 / 唾液中EGF

Outline of Final Research Achievements

The effects of salivary secretion on the development of RE, including PPI-resistant severereflux esophagitis (RE), and non-erosive reflux disease (NERD) was investigated. Asignificant reduction in salivary secretion was reported in PPI-resistant severe REcompared with PPI-responsive severe RE. In addition, salivary secretion was reported to be significantly reduced in mild RE and NERD compared with healthy subjects. When examined by gender, we reported that there were no differences in salivary secretion in male mild RE, but a significant reduction in salivary secretion in female mild RE. A gender-specific study of NERD also showed that salivary secretion is significantly reduced in female NERD. The study is currently being submitted for publication.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

胃食道逆流症患者の唾液分泌には性差が存在し、女性の軽症逆流性食道炎、非びらん性逆流症患者では唾液分泌が病態に関連している可能性があることを示せたことが本研究の研究成果である。現在まで逆流性食道炎、NERD（true NERD）の病態に関しては胃酸逆流を中心に論じられてきた。今回、酸逆流以外に唾液の関与の可能性を示したことが本研究の学術的意義である。本邦にはこれらの患者は多数いることから、薬物に頼らない唾液をターゲットとした新たな治療法の開発への可能性を示した本研究成果の社会的意義は大きい。