Study of molecular basis of motilin and growth hormone secretagogue receptor

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08333
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Ehime University
• Principal Investigator: Matsuura Bunzo 愛媛大学, 医学系研究科, 寄附講座教授 (80284420)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: モチリン受容体 / グレリン受容体 / モチリン / エリスロマイシン / グレリン / 受容体脱感作 / トランスジェニックマウス / 脳－腸相関

Outline of Final Research Achievements

Motilin, erythromycin and ghrelin are important regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor (MLNR) and growth hormone secretagogue receptor (GHSR). We have clarified pre-stimulation with motilin induces desensitization of MLNR, while that with erythromycin does not. Intracellular GRK and b-arrestin are found to be involved in differences of the desensitization. We also have clarified gastric motility in anxiety model of MLNR transgenic mice is improved by MLNR agonist.

Free Research Field

消化器病学

Academic Significance and Societal Importance of the Research Achievements

モチリン受容体におけるエリスロマイシン刺激では，細胞内GRK，b-arrestinの作用により脱感作が生じにくいため，種々の病態における消化管運動機能異常の改善に有用であることが確立された。