Development of new strategy for the treatment of cardiovascular disease using adipose tissue.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Nagoya University
• Principal Investigator: Shibata Rei 名古屋大学, 医学系研究科, 特任教授 (70343689)
• Co-Investigator(Kenkyū-buntansha): 室原 豊明 名古屋大学, 医学系研究科, 教授 (90299503)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 血管新生 / 重症虚血肢 / 脂肪組織由来間葉系前駆細胞 / 幹細胞

Outline of Final Research Achievements

The ageing of the population has led to a marked increase in the number of patients with cardiovascular disease. Angiogenic therapy is becoming established as a new treatment strategy for such cases. In our study, transplantation of Adipose-derived Regenerative Cells in patients with severe ischemic limbs resulted in reduced pain and ulcer size, and amputation of the affected limb was avoided. Possible mechanisms include modulation of VEGF secretion, suppression of inflammation and promotion of wound healing. The results also showed that VEGF-A isoforms and zinc levels in the blood may be promising predictors of the therapeutic effect.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

重症虚血肢患者では、切断を余儀なくされる症例は少なくない。切断を選択する前の新たな治療選択肢として、今回我々が行った「脂肪組織由来間葉系前駆細胞を用いた重症虚血肢に対する血管新生療法」が一定の効果を示した。また、その機序に関しても、その一部が明らかとなった。これらの成果は、「心血管系に対する安全で効果的な再生医療」の確立につながると考えられる。