2022 Fiscal Year Final Research Report
The roles of macrophages in cardiac remodeling
Project/Area Number |
20K08418
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53020:Cardiology-related
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Research Institution | Jichi Medical University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 心臓病 / 線維化 / マクロファージ |
Outline of Final Research Achievements |
Excessive fibrosis develops in pressure-overloaded heart, leading to the occurrence of heart failure. During fibrogenesis, macrophages or other inflammatory cells are recruited to the heart. However, the roles of these inflammatory cells in cardiac fibrosis are not fully elucidated. In this study, we studied the molecular processes of cardiac remodeling by focusing on the roles of cardiac macrophages. We analyzed the expression of inflammatory cytokines, and identified several cytokines were highly expressed in cardiac macrophages. We next tested the roles of these cytokines and identified the cytokines those suppressed fibroblast activation in vitro. These cytokines may have a potential to suppress cardiac fibrosis in vivo. Elucidation the link between cardiac macrophages and fibroblast will give us further insights in the molecular processes of cardiac remodeling.
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Free Research Field |
循環器病学
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Academic Significance and Societal Importance of the Research Achievements |
本研究では心臓に集積する炎症細胞であるマクロファージに着目し、心不全、心臓線維化の病態形成に関わる炎症性サイトカインの探索を行った。その結果、心臓線維化を抑制する可能性のあるサイトカイン候補を抽出することが出来た。引き続き様々な病態モデルを用いた解析を行うことで、心臓線維化の病態における炎症性サイトカインの役割を明らかにしていくことができると考えられる。これらのアプローチにより、心臓線維化、心不全に対する新たな治療標的の同定および診断マーカーの確立へと展開できると期待される。
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