2022 Fiscal Year Final Research Report
A novel strategy in diagnosis and therapy for acquired vonwillebrand syndrome associated with cardiovascular disease
| Project/Area Number |
20K08479
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 雅則 奈良県立医科大学, 医学部, 教授 (60316081)
井上 雄介 旭川医科大学, 医学部, 准教授 (80611079)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | von willebrand factor / 後天性フォンヴィレブランド症候群 |
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| Outline of Final Research Achievements |
Firstly, We developed analytical method for acquired von willebrand syndrome (AVWS), associated with cardiovascular disease. By 2022, we received patent and achieved excellent presentation awards for three years at congress of Japanese Society for Artificial Organs. The appropriate standardization of analytical method for AVWS gave pioneering research initiated by the next generation. Secondary, We analyzed von willebrand factor with patients provided cardiopulmonary bypass for cardiac surgery. The diagnosis, bleeding risk and severity of AVWS were estimated to define with these result of patients. All patients revealed lack of high molecular von willebrand factor(HM-VWF) during support with cardiopulmonary bypass. Despite our expectations, almost patients developed lack of HM-VWF after surgery. This study evaluated the no relationship between bleeding events and lack of HM-VWF in patients after surgery, but suggested possibilty of pulmonary embolism.
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| Free Research Field |
血栓止血
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| Academic Significance and Societal Importance of the Research Achievements |
後天性フォンヴィレブランド症候群(AVWS)の機序の解明のため1)AVWSを再現する実験機を作成し学会報告した。今後研究方法として標準化としてしつつあると思われる。今後、VWFがどのような条件で切断されるかの実験の礎を築くことに成功した。2）AVWSの診断、出血リスク、重症度の解析として奈良県立医科大学における人工心肺を利用した手術症例の周術期の患者のVWFマルチマー解析を行った。出血所見を認めない症例でも高頻度で高分子VWFが欠損していることを明らかにした。高分子VWFの欠損と出血事象に注目していたが、肺血栓塞栓症などの血管閉塞を示すマーカーとしてVWFが有用である可能性が示された。
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