2022 Fiscal Year Final Research Report
Effect of Secma1a on the neutrophil recruitment during pneumococcal pneumonia
| Project/Area Number |
20K08523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Keio University |
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Principal Investigator |
Kamata Hirofumi 慶應義塾大学, 医学部(信濃町), 特任講師 (60528545)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 肺炎球菌肺炎 |
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| Outline of Final Research Achievements |
The aim of this project is to elucidate the mechanism through which neutrophils migrate into the lung, mediated by epithelial-derived Sectm1a. In this study, we use Secmt1 knockout mice. We found that Sectm1a have significant effect on a specific lymphocyte subset, which regulates neutrophil migration. We are keeping on working to elucidate the more detailed mechanism of this effect.
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| Free Research Field |
気道感染症免疫
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| Academic Significance and Societal Importance of the Research Achievements |
最も市中肺炎のなかで頻度が高く、糖尿病や肺気腫など基礎疾患のある患者においてしばしば重症化する肺炎球菌肺炎の病態をより詳細に解明し、抗菌薬に加えたあらたな治療薬、治療戦略の開発につなりうる研究である。
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