2021 Fiscal Year Research-status Report
The interaction between High Fat Diet, lung stem cells, and lung fibrosis
| Project/Area Number |
20K08548
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| Research Institution | Keio University |
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Principal Investigator |
ヒガブ中井 アハマド 慶應義塾大学, 医学部(信濃町), 共同研究員 (00507915)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | High fat diet / fatty a. oxidation / fibrosis / bronchioalveolar cells / alveolar type-2 cells |
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| Outline of Annual Research Achievements |
We continued to explore further the effect of High fat diet on lung repair after a fibrosis-inducing injury, focusing on the effect on lung stem cells. We previously reported that High fat diet delayed the contribution of alveolar stem cells in the repair process and delayed the resolution of inflammation and fibrosis compared to the standard diet. Now we are focusing on the specific role of bronchioalveolar stem cells in this delay. Bronchioalveolar stem cells are rare in the lung compared to alveolar cells, so identifying their critical influence on repair will represent a major advance in our knowledge. We are also examining the effect of various inhibitors of Fatty Acid Oxidation on the high fat diet-induced delay in alveolar repair and fibrosis resolution.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
We almost finished the original plan and are now expanding our experiments to get a better understanding of the mechanisms involved.
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| Strategy for Future Research Activity |
We planned this last year but was delayed due to some Corona-related logistics. We are considering it again, that is performing a comprehensive lipidomic analysis on the mice lungs to find out what are the lung metabolites that were
influenced by the high fat diet, and how it affected the lung stem cells.
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| Causes of Carryover |
We will use this amount to gather more data regarding the mechanism by which high fat diet delayed the lung repair. We will also use it to cover the expenses of presenting our data in the ISSCR annual conference.
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