2022 Fiscal Year Annual Research Report
The interaction between High Fat Diet, lung stem cells, and lung fibrosis
| Project/Area Number |
20K08548
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
ヒガブ中井 アハマド 慶應義塾大学, 医学部(信濃町), 共同研究員 (00507915)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | High fat diet / Fatty acids / Fibrosis / bronchioalveolar cells / Alveolar type-2 cells |
|---|
| Outline of Annual Research Achievements |
We have explored the effect of High fat diet on lung repair after a fibrosis-inducing injury, focusing on the effect on lung stem cells. We previously reported that High fat diet delayed the contribution of alveolar stem cells in the repair process and delayed the resolution of inflammation and fibrosis compared to the standard diet. In these new studies, we have identified the specific role of bronchioalveolar stem cells in this delay. Bronchioalveolar stem cells are rare in the lung compared to alveolar cells, so identifying their critical influence on repair represents a major advance in our knowledge. We also examined the effect of various inhibitors of Fatty Acid Oxidation on the high fat diet-induced delay in alveolar repair and fibrosis resolution.
|
