2022 Fiscal Year Final Research Report
The interaction between High Fat Diet, lung stem cells, and lung fibrosis
Project/Area Number |
20K08548
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53030:Respiratory medicine-related
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Research Institution | Keio University |
Principal Investigator |
Hegab Ahmed E 慶應義塾大学, 医学部(信濃町), 共同研究員 (00507915)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | lung stem cells / lung fibrosis / high fat diet |
Outline of Final Research Achievements |
We have explored the effect of High fat diet on lung repair after a fibrosis-inducing injury, focusing on the effect on lung stem cells. We previously reported that High fat diet delayed the contribution of alveolar stem cells in the repair process and delayed the resolution of inflammation and fibrosis compared to the standard diet. In these new studies, we have identified the specific role of bronchioalveolar stem cells in this delay. Bronchioalveolar stem cells are rare in the lung compared to alveolar cells, so identifying their critical influence on repair represents a major advance in our knowledge. We also examined the effect of various inhibitors of Fatty Acid Oxidation on the high fat diet-induced delay in alveolar repair and fibrosis resolution.
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Free Research Field |
lung stem cells
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Academic Significance and Societal Importance of the Research Achievements |
Our results helps to improve our understanding of how the high fat diet negatively influence the lung repair such as after an injury that induces fibrosis. Our results explains that such negative effect of high fat diet happens because of an inhibitory effect on lung stem cells.
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