Role of 'immnue memory' of airway epithelial cells in asthma

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K08562
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Chiba University
• Principal Investigator: Yokota Masaya 千葉大学, 大学院医学研究院, 特任助教 (70721950)
• Co-Investigator(Kenkyū-buntansha): 田中 繁 千葉大学, 医学部附属病院, 助教 (30822051) ; 岩田 有史 千葉大学, 大学院医学研究院, 助教 (90436353)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 気管支喘息 / 気道上皮細胞 / STAT3 / SCD1

Outline of Final Research Achievements

Airway epithelial cells (AECs) play a crucial role in the induction and development of allergic inflammation through the development and activation of immune cells, including type 2 helper T cells and type 2 innate lymphoid cells. However, the role of STAT3 expressed in airway epithelium is largely unknown. We have shown that STAT3 and its downstream, SCD1（stearoyl-CoA desaturase 1）in airway epithelial cells, play an important role in suppressing allergic airway inflammation.

Free Research Field

リウマチ、アレルギー、膠原病

Academic Significance and Societal Importance of the Research Achievements

アレルギー性気道炎症における上皮細胞STAT3の役割として、SCD1を介した炎症抑制という新たな知見を示し、喘息の新規治療標的を見出した点で大きな意義がある。