2022 Fiscal Year Final Research Report
Vaspin inhibits tubulointerstitial injury via maintaining mitochondrial homeostasis
| Project/Area Number |
20K08608
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | アディポカイン / Vaspin / ミトコンドリア / 糖尿病腎症 / 尿細管間質障害 |
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| Outline of Final Research Achievements |
Tubular interstitial injury is a major risk for renal dysfunction. Tubular cells have high energy demands due to their multifunctional cellularity, and mitochondria are among the most abundant cells, so it is important to maintain mitochondrial function. In this study, we show that Vaspin, secreted by adipocytes, reaches the kidney via the blood and maintains mitochondrial function via HSPA1L, reducing tubulointerstitial damage in diabetic nephropathy.
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| Free Research Field |
糖尿病・代謝学、腎臓病学
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| Academic Significance and Societal Importance of the Research Achievements |
バスピンのミトコンドリア恒常性維持における意義を解明することは、今後、腎臓以外にも、心臓や褐色脂肪など、ミトコンドリアが豊富な臓器や細胞に関する病態の解明や、疾患治療への応用が可能と考えられる。
また、これまで十分機能が解明されていないHSPA1Lの機能を明らかにすることは、学術的な今後の研究の広がりにつながる。
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