2022 Fiscal Year Final Research Report
(Pro)renin receptor and renal fibrosis
| Project/Area Number |
20K08612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Tohoku University |
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Principal Investigator |
Hirose Takuo 東北大学, 医学系研究科, 助教 (20599302)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | (プロ)レニン受容体 / 線維化 / 腎臓 / レニン・アンジオテンシン系 / 形質転換 / 尿細管障害 / 周皮細胞 |
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| Outline of Final Research Achievements |
The (pro)renin receptor [(P)RR] is identified as a component of the renin-angiotensin system and this has been shown to be involved in many human diseases. To elucidate the pathophysiological role of (P)RR in renal fibrosis, we performed experiments in human, animals, and cultured cells. (P)RR contributes to renal fibrosis by regulating V-ATPase function and the transport of fibrotic proteins such as fibronectin and collagen to the extracellular space.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究のヒト及び動物実験、培養細胞を用いた検討により、腎臓線維化における(P)RRの病態生理学的役割が明らかとなった。腎臓線維化において、(P)RRは維化タンパク質の細胞外への輸送をV-ATPaseを介して制御していた。これまで(P)RRを標的する薬剤は開発されておらず、本研究成果が腎臓線維化に対する新たな予防・治療戦略の基盤となることが期待される。
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