Analysis of factors in the stratum corneum from the neonatal period in infants at high risk of developing atopic dermatitis

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Yoshida Kazue 国立研究開発法人国立成育医療研究センター, 小児外科系専門診療部, 診療部長 (70383776)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 乳児 / 新生児 / 皮膚 / 角層 / 共焦点ラマン分光装置

Outline of Final Research Achievements

In this study, skin examination by a physician and analysis of stratum corneum factors by confocal Raman spectroscopy were conducted from neonatal period to 1 year of age to analyze the relationship between changes in the skin barrier during infancy and dermatitis that develops during infancy. The stratum corneum barrier changes significantly during infancy, suggesting an association with infantile seborrheic dermatitis and atopic dermatitis that develop during this period, which is an important finding in understanding the pathogenesis of dermatitis that develops during infancy.

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

本研究により出生直後から1歳までの角層内因子の経時的な変化が観察され、乳児期の皮膚バリアや皮膚炎の病態を理解する上で重要な知見が得られた。さらに、臨床的に明らかに乳児脂漏性皮膚炎や乳児アトピー性皮膚炎を発症する前に、角層内因子の変化が生じていることを示唆するデータが得られた。乳児期の脂漏性皮膚炎やアトピー性皮膚炎発症の病態や早期診断、予後予測に繋がる有用な知見と考えられ、社会的意義は大きい。