2022 Fiscal Year Final Research Report
Functional analyses of type VII collagen driven from keratinocytes for hair follicles
| Project/Area Number |
20K08665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
澤村 大輔 弘前大学, 医学研究科, 教授 (60196334)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | type VII collagen / keratinocyte |
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| Outline of Final Research Achievements |
We confirmed that NC2-cKO mice, which the expression of NC2 domain is abolished in keratinocytes, showed gradually gray hair and hair loss around 20 weeks old. On the dorsum skin of NC2-cKO mice, normal hair follicles disappeared. Furthermore, the number of sebaceous glands decreased. We successfully established mesenchymal stem cells driven from fat tissues of normal mice. We injected these cells around skin graft from NC2-cKO mice on the Rag2 mice every week. Unfortunately, mesenchymal stem cells did not show the induction of hair growth.
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| Free Research Field |
dermatology
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| Academic Significance and Societal Importance of the Research Achievements |
COLVIIが互いに結合し最終的に三重らせん構造を呈するためには、NC2領域での結合が重要である。COLVIIが関わる脱毛を解析することは毛髪老化現象による壮年性脱毛、頭髪の白毛化の発生機序解明につながると考える。本研究は、COLVII欠損の表皮水疱症患者へ新規COLVIIを提供する基盤となる研究課題であり、また脱毛・白毛化の改善という一般社会にも研究成果が波及することが期待できる創造性をもった研究である。
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