2022 Fiscal Year Final Research Report
Pathological involvement of Schwann cells in cutaneous allergic diseases.
| Project/Area Number |
20K08689
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Kindai University (2021-2022)
Kyoto University (2020) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 接触皮膚炎 / シュワン細胞 |
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| Outline of Final Research Achievements |
The role of peripheral nerves in skin allergy diseases is gaining attention, with a focus on distinguishing nerve fibers and Schwann cells. Schwann cell-specific optogenetic mice were created for basic analysis, but in a contact dermatitis model, inflammation didn't differ from control mice. Single-cell RNA sequencing revealed subsets of Schwann cells in the epidermis.
In a Staphylococcus aureus-induced dermatitis model, many eosinophils infiltrated the skin, and RTX treatment revealed the importance of peripheral nerves and Schwann cells. Both produced chemokines, and TLR2 KO mice showed reduced inflammation with eosinophils and basophils being the main inflammatory cells. The direct impact of Schwann cells on skin allergy reactions remains unclear, but nerve fibers' contribution to inflammation is suggested. Future research will explore Schwann cells' potential involvement in skin diseases.
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| Free Research Field |
皮膚アレルギー疾患
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| Academic Significance and Societal Importance of the Research Achievements |
皮膚アレルギー疾患における末梢神経の役割を研究しました。神経軸索とシュワン細胞から成る末梢神経の解析に焦点を当て、シュワン細胞特異的光刺激マウスを作成し基礎的解析を行いました。接触皮膚炎の程度に差はありませんでしたが、シングルセルRNAシークエンスを用いてシュワン細胞の解析を行い、サブセットが存在することが分かりました。
黄色ブドウ球菌による皮膚炎モデルで、好塩基球が皮膚に浸潤することを確認し、神経軸索とシュワン細胞が炎症に関与する可能性が示唆されました。今後は、シュワン細胞が影響を与える皮膚疾患の可能性について検討し、皮膚アレルギー疾患の理解を深め、治療法の開発に寄与することが期待されます。
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