Integrated functional analysis of lncRNAs in hematopoietic tumors using the Ab initio method

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08716
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Mori Tsutomu 福島県立医科大学, 看護学部, 准教授 (60244373)
• Co-Investigator(Kenkyū-buntansha): 合山 進 東京大学, 大学院新領域創成科学研究科, 教授 (80431849)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: bioinformatics / long non-coding RNA / hematopoietic tumors / ab initio 遺伝子軌道法

Outline of Final Research Achievements

This study was initiated to elucidate the physiological functions of long non-coding RNAs (lncRNAs) and their roles in pathological conditions. lncRNAs are still largely unexplored in terms of their diverse functions and interactions, and their detailed analysis is of great importance in the life sciences and medicine. In particular, lncRNAs associated with hematopoietic tumors have not been well studied, and their elucidation may lead to the development of new therapeutic strategies. In this study, we analyzed the gene network structure and function of lncRNAs using the ab initio genetic orbital method and identified lncRNAs specifically associated with hematopoietic tumors. The lncRNAs identified were LINC00635, LINC00636, and LINC01591. These lncRNAs are involved in the cell cycle, DNA damage repair, cell migration, and immune response, and may play important roles in hematopoietic tumor progression and therapy.

Free Research Field

Information theory of gene networks

Academic Significance and Societal Importance of the Research Achievements

今回の研究で、LINC00635、LINC00636、LINC01591の3つのlncRNAが造血器腫瘍との関連性が強いことが示された。これらlncRNAは、細胞周期、DNA損傷修復、細胞移動および免疫応答に関与しており、造血器腫瘍の進行や治療において重要な役割を果たす可能性がある。今後は、これらのlncRNAの機能を更に詳細に解析し、治療標的としての可能性を探るためのwet実験を進めていく予定である。この研究成果は、lncRNAの機能解析および造血器腫瘍の治療における新たな視点を提供するものであり、今後の研究に大きな貢献をすることが期待される。