Molecular mechanisms in vascular epithelial cells involved in the pathogenesis of dengue hemorrhagic fever

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54030:Infectious disease medicine-related
• Research Institution: Nagasaki University
• Principal Investigator: NABESHIMA Takeshi 長崎大学, 熱帯医学研究所, 助教 (30546859)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: デング出血熱 / 血漿漏出 / トランスクリプトーム / 細胞接着

Outline of Final Research Achievements

After this research plan was proposed and adopted, a coronavirus pandemic broke out, forcing a major change in the plan regarding the collection of samples from virus-infected patients overseas. Therefore, we applied for an extension of the research institute and were discussing ways to take tetas that would meet the objectives of the original plan, when Associate Professor Takamatsu of the principal investigator's laboratory suggested that we outsource the analysis of samples to an outside contractor and take data for next-generation sequencing. Currently, the samples have been submitted to Azenta (formerly Genewiz) and we are waiting for a report on the results.

Free Research Field

公衆衛生学

Academic Significance and Societal Importance of the Research Achievements

本研究のデータから、デング出血熱の患者における血管からの血漿の漏出について、in vitro系を用いた遺伝子発現プロフィールに基づいた清浄の解析が可能になると期待される。