Development of novel therapies for bacterial infections by linking the host immune mechanism with the action of the bacterial flora.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08842
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54030:Infectious disease medicine-related
• Research Institution: Yamaguchi University (2023); Nagasaki University (2020-2022)
• Principal Investigator: Sakamorto Kei 山口大学, 大学院医学系研究科, 教授 (10528300)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 細菌感染 / 敗血症 / 食中毒

Outline of Final Research Achievements

In this study, we sought to develop an antimicrobial-independent treatment for bacterial infections in order to increase treatment options for bacterial infections. Animal studies were conducted in mice and used Escherichia coli and its relatives Citrobacter rodentium, Klebsiella pneumoniae, and Staphylococcus aureus.
The Escherichia coli and Citrobacter rodentium infection models were primarily treated by oral administration of immunoglobulin. On the other hand, for Staphylococcus aureus infections, we developed an inflammasome-regulated therapy.
We also reported on the biological characteristics of the ST131 strain of E. coli.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

抗菌薬に耐性をもつ細菌（薬剤耐性菌）による感染症が世界的に問題になっている。しかし細菌感染症に対する治療法は、抗菌薬に依存する他ないのが現状である。この状況を打開するため、抗菌薬非依存的な細菌感染に対する治療法を開発する必要に迫られている。
本研究はこの問題の解決を目指し、細菌や宿主の生物学的特性を利用した治療法の開発に取り組んだ。