2023 Fiscal Year Final Research Report
Verification of systemic response and tumor microenvironment change in triple-negative breast cancer based on immune response
| Project/Area Number |
20K08938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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| Research Institution | Osaka Metropolitan University (2022-2023)
Osaka City University (2020-2021) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浅野 有香 大阪公立大学, 大学院医学研究科, 病院講師 (10806376)
藤田 寿一 大阪公立大学, 大学院看護学研究科, 准教授 (30212187)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 乳癌 / 腫瘍微小環境 / 腫瘍免疫 / トリプルネガティブ乳癌 / 免疫療法 |
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| Outline of Final Research Achievements |
Tumor tissues present a characteristic environment called the tumor microenvironment (TME) due to interactions between cancer cells and surrounding stromal cells. Since evaluation of the TME in the host is related to predicting therapeutic effects and prognosis, monitoring the TME is a key factor in cancer treatment.
In this study, titled "Verification of systemic reactions and microenvironmental changes in triple-negative breast cancer as seen from immune responses," we examined next-generation personalized breast cancer drug therapy centered on immunotherapy. It was suggested that immunotherapy may enhance tumor immunity by using anticancer drugs in combination.
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| Free Research Field |
乳癌
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| Academic Significance and Societal Importance of the Research Achievements |
腫瘍微小環境は薬剤修飾によりダイナミックな変化を示すために，この動的な変化をモニタリングすることでトリプルネガティブ乳癌の新たな治療戦略の構築に寄与する可能性が示された．
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