2023 Fiscal Year Final Research Report

The Innovative Therapeutic Strategy in Kidney Transplant - The Roles of Dendritic Cells in IR injury -

Research Project

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Project/Area Number	20K08994
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 55010:General surgery and pediatric surgery-related
Research Institution	Tokyo Medical University
Principal Investigator	UENO TAKUYA 東京医科大学, 医学部, 兼任講師 (00296469)
Co-Investigator(Kenkyū-buntansha)	岩本整東京医科大学, 医学部, 教授 (00338831) 竹内裕紀東京医科大学, 医学部, 薬剤部長 (20439912) 高原史郎大阪大学, 大学院医学系研究科, 招へい教授 (70179547) 池田寿昭東京医科大学, 医学部, 教授 (90246182) 尾田高志東京医科大学, 医学部, 教授 (90531187)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	移植臓器 / 血液浄化 / 虚血再灌流障害 / サイトカイン
Outline of Final Research Achievements	Due to the lack of numbers of organ grafts in transplantation, our group has been developing a new organ preservation system to maintain preserved harvested grafts during cold ischemic time. In the current study, our group employed an acute blood purification which has been utilized in ICU and ER settings to rescue patients with sepsis and organ failures due to septic shock and DIC. One of major findings from the current study, we have reported the advantages of acute blood purification/ column in organ preservation system via the reduction of inflammatory cytokines and meditators (Frontiers in Medicine, 2023). In particular, interactions between IL-6 and PAI-1 can be maintained through the system which results in better outcomes in septic patients. It means that employing the system could be a new therapeutic approach to regulate the cytokine storm that is one of major concerns in transplantation research.
Free Research Field	外科、移植、臓器保存、人工臓器
Academic Significance and Societal Importance of the Research Achievements	ドナープールの減少（移植臓器数のアンバランス：移植希望数/臓器提供数）はこれまでも大きな問題であり、これからも立ちはだかる事が予想される解決すべき重要課題である。その中で本研究で得られた”新たなドナープール開拓の為の人工臓器の基礎的研究” の成果はそれらを払拭する可能性を秘めている。特に血液浄化カラムを介した新たな臓器保存法の着想（基盤C: 23K08746, 樹状細胞-血管内皮障害軽減を介した新たな臓器保存法開発への取組み）に至った経緯は大きく、更なる移植件数の向上に繋がる成果と言える。