2023 Fiscal Year Final Research Report
Development of a Novel Reconstructive Technique for Esophageal Surgery Using ICG Fluorescence Blood Flow Visualization and Artificial Intelligence Analysis
Project/Area Number |
20K09010
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Kochi University |
Principal Investigator |
Kitagawa Hiroyuki 高知大学, 教育研究部医療学系臨床医学部門, 講師 (10403883)
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Co-Investigator(Kenkyū-buntansha) |
岩部 純 高知大学, 医学部附属病院, その他 (00553877)
並川 努 高知大学, 教育研究部医療学系臨床医学部門, 講師 (50363289)
花崎 和弘 高知大学, 教育研究部医療学系臨床医学部門, 教授 (30240790)
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | 食道外科 / 縫合不全 / 胃管再建 / 血流評価 / ICG蛍光法 / Time intensity curve / プログラミング |
Outline of Final Research Achievements |
The purpose of this study was to establish a quantitative evaluation method of blood flow in esophageal cancer surgery by constructing a time-intensity curve (TIC) from videos of blood flow evaluation of reconstructed gastric tubes by ICG fluorescence method. Four regions of interest (ROIs) were set around the planned anastomosis of the elevated gastric tube, and TICs were constructed by programming using the OpenCV Library in Python to examine the relationship with the incidence of anastomotic leakage. Of 97 cases, TIC was successfully constructed in 65 cases, and the causes of TIC failure were gastric tube movement during imaging and poor fluorescence intensity. The intensity starting point of the ROI was faster than the ICG visualization time by visual assessment by the surgeon, suggesting the sensitivity of TIC evaluation. The group with anastomotic leakage tended to have a slower intensity starting point in ROI 3 (22.5 vs. 19.0 s; P=0.087).
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Free Research Field |
食道外科
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Academic Significance and Societal Importance of the Research Achievements |
本研究によって手術動画からプログラミングを用いてTICを構成する場合に障害となる要素を抽出することができた。この結果をもとに信頼性の高いTIC構成されることで、術中蛍光輝度評価の客観的かつ定量的評価方法が、および縫合不全を回避する血流評価方法が確立されることが期待される。
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