Investigation of the cause of gastric cancer peritoneal dissemination by exosome-encapsulated microRNA/gene regulation

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Kumamoto University
• Principal Investigator: Kurashige Junji 熊本大学, 大学院生命科学研究部(医), 特定研究員 (90594474)
• Co-Investigator(Kenkyū-buntansha): 江藤 弘二郎 熊本大学, 病院, 特任助教 (40585717) ; 原田 和人 熊本大学, 大学院生命科学研究部(医), 特定研究員 (70608869) ; 山下 晃平 熊本大学, 大学院生命科学研究部(医), 特定研究員 (00867202)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 胃癌 / 腹膜播種 / SERPINE2 / 細胞外マトリックス

Outline of Final Research Achievements

Using a mouse model of peritoneal dissemination, we searched for genes that are significantly involved in peritoneal dissemination of metastasis and that significantly determine the prognosis of gastric cancer patients as potential therapeutic targets. We found that the gene SERPINE2 is a component of the extracellular matrix, and that overall survival and recurrence-free survival tended to be lower in the group with high SERPINE2 expression, suggesting that SERPINE2 This suggests that SERPINE2 expression influences prognosis. In addition, the frequency of gastric cancer peritoneal dissemination was significantly higher in the group of patients with high SERPINE2 expression, and since existing anticoagulants exist as inhibitors of SERPINE2, we are investigating whether these agents are effective against gastric cancer peritoneum in vivo.

Free Research Field

消化器外科学、腫瘍医学

Academic Significance and Societal Importance of the Research Achievements

スキルス胃癌は若年者に発症し、高い死亡率を有するにも関わらず、これまで解明されている情報は極めて限られており、腹膜播種転移機序については未知な部分が多く、有効な予防法や治療法は依然確立していない。SERPINE2に関しては、既存の抗凝固薬がその抑制薬剤として存在しており、実臨床で用いるハードルも低く、癌の進展を抑制させる可能性があり、新しい胃癌腹膜播種の治療につながる可能性がある。